Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series : World's leading Event Organizer

Back

Miklos Fuzi

Miklos Fuzi

Semmelweis University, Hungary

Title: Diverse fitness associated with resistance to fluoroquinolones influenced the clonal dynamics of various multiresistant pathogens

Biography

Biography: Miklos Fuzi

Abstract

Fitness cost associated with resistance to fluoroquinolones was recently shown to vary across clones of methicillin-resistant
Staphylococcus aureus (MRSA) and extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae. The resulting
dissimilar fitness should have influenced the clonal dynamics and thereby the rates of resistance for these pathogens. Moreover, a
similar mechanism was recently proposed for the emergence of the H30 and H30R lineages of ESBL-producing E. coli and the major
international clone (ribotype 027) of Clostridium difficile. The overwhelming part of the available epidemiological data supports
the connection. An ability to develop favorable mutations in the gyrase and topoisomerase IV genes seems to be a prerequisite for
pathogens to retain fitness while showing high-level resistance to fluoroquinolones. Moreover, the mechanism was observed to select
for the CTX-M-15 type ESBL in K. pneumoniae that may account for the widespread dissemination of this enzyme. The findings
suggest that the use of fluoroquinolones as a function of clonal distribution could ameliorate the state of antibiotic resistance. When
the proportions of multiresistant clones influenced by fluoroquinolones are low the use of these antibiotics remains highly beneficial.
However when their proportion increases the consumption of fluoroquinolones should transiently be reduced.